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Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
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Effect of cimetidine on burst-promoting activity of normal T lymphocytes

L Morra1, F Moccia, P Casti

  • 1Chair of Medical Therapy, Department of Internal Medicine, University of Genova, Italy.

Annals of Hematology
|May 1, 1992
PubMed

The effect of cimetidine, an inhibitor of suppressor T lymphocytes, on the burst-promoting activity (BPA) of normal T lymphocytes has been studied. Cimetidine has been shown to increase the BPA of normal T lymphocytes, both when added to the culture and when T lymphocytes were preincubated for 1 h with it. Cimetidine had no direct effect on the in vitro growth of burst-forming units (BFU-E). Our results show that CD8 suppressor T lymphocytes inhibit the in vitro growth of BFU-E in normal conditions, either directly or through inhibition of BPA of CD4 helper T lymphocytes. Cimetidine has proved to be a useful tool for investigating the hematological role of T-lymphocyte subsets in normal and pathological conditions.

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