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Association between infection with Helicobacter pylori and cerebral noncardioembolic ischemic stroke

S A Masoud1, M A Arami, E Kucheki

  • 1Neurology Department, Shahid Beheshty Hospital, Kashan University of Medical Sciences, Iran. arami_ma@yahoo.com

Neurology India
|October 19, 2005
PubMed

Insights

This study found a link between prior Helicobacter pylori infection and noncardioembolic ischemic stroke. Evidence suggests the immune response to H. pylori may be a risk factor for this type of stroke.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Research

Background:

  • Helicobacter pylori infection is linked to coronary artery atherosclerosis.
  • The association between H. pylori and cerebral noncardioembolic ischemia is unclear.

Purpose of the Study:

  • To investigate the association between H. pylori infection and noncardioembolic ischemic stroke using a case-control design.

Main Methods:

  • A case-control study included patients with first ischemic stroke and matched controls.
  • Exclusion criteria targeted patients with cardiac sources of emboli or major stroke risk factors.
  • Enzyme immunoassay measured IgG and IgA antibodies to H. pylori.

Main Results:

  • Seropositivity for H. pylori was higher in stroke cases (72.5%) compared to controls (56.3%).
  • Mean serum IgG levels were significantly elevated in the stroke group (P < 0.005).
  • IgA antibody elevation did not show a significant association with stroke risk.

Conclusions:

  • The study provides evidence for an association between the immune response to H. pylori and noncardioembolic ischemic stroke.
  • Prior H. pylori infection, indicated by immune response, may be a marker for increased risk of noncardioembolic ischemic stroke.
Abstract

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