Related Experiment Video
Updated: Aug 15, 2026
03:24
A Suture Technique for Ruptured Annulus Fibrosus Following Decompression Under Percutaneous Transforaminal Endoscopic Discectomy
Published on: January 26, 2024
[Perforating granuloma annulare with transfollicular perforation]
Annales De Dermatologie Et De Venereologie
|October 19, 2005
Summary
Perforating granuloma annulare is a rare skin condition. Histological confirmation is key for diagnosis, especially with unique presentations like a single ulcerated lesion.
Area of Science:
- Dermatology
- Pathology
Background:
- Perforating granuloma annulare (PGA) is a rare variant of granuloma annulare.
- Clinical diagnosis of PGA is challenging, often requiring histological confirmation.
- Unique localization occurs in less than 10% of cases.
Observation:
- A 36-year-old woman presented with a year-long solitary, ulcerated nodular lesion on her upper arm.
- Clinical and biological evaluations were unremarkable.
- Histological examination revealed perforating granuloma annulare with significant epidermal ulceration.
Findings:
- Histopathology confirmed perforating granuloma annulare with a large epidermal ulceration.
- Evidence of hair follicle infiltration and destruction suggested transfollicular elimination of necrotic material.
- Other conditions with palisading granuloma histology were excluded.
Implications:
- The solitary nature of the lesion prompted differential diagnosis including cutaneous tuberculosis, mycobacteriosis, sarcoidosis, foreign body granuloma, and carcinoma.
- The exact pathophysiology and perforation mechanism in PGA remain unclear.
- Treatment outcomes for PGA are variable, highlighting the need for further research.
Related Concept Videos
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:26Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
01:20Folliculogenesis
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
01:22Esophageal Perforation-I: Introduction
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
01:30Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...