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Updated: Aug 9, 2026
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
[Thymic neuroendocrine tumors: report on 6 cases]
Lara Chalabreysse1, Carole Gengler, Sana Sefiani
1Service d'Anatomie et de Cytologie Pathologiques, Hôpital Louis Pradel, 28 avenue du doyen Lépine, 69677 Bron Cedex. lara.chalabreysse@chu-lyon.fr
Aim:
the aim of our study was to analyze a series of 6 thymic neuroendocrine tumors (TNET).
Methods:
we report the clinical and pathological features of 6 TNET reclassified according to the last WHO classification (2004).
Results:
there were 4 men and 2 women, (mean age of 61.3 years), presenting with local symptoms in 4 cases. The tumors were reclassified as 3 atypical carcinoids (AC), 2 small cell carcinomas (SCC) and 1 large cell neuroendocrine carcinoma (LCNEC). Cytokeratin, EMA and neuroendocrine markers were expressed in poorly-differentiated tumors. Two patients were lost of follow-up. Two patients with AC died of disease at 20 and 36 months. One patient with SCC died of disease at 2 years and the patient with the LCNEC died of disease in 3 months.
Conclusion:
TNET are poor prognosis tumors with a prognosis similar to thymic carcinomas. Adequate surgical resection is a strong prognosis factor.
