Related Experiment Video
Updated: Aug 15, 2026
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Assessment of left ventricular ejection fraction measured by quantitative gated SPECT: correlation with left
Koichiro Abe1, Koichi Hirakawa, Takenori Yonenaga
1Department of Radiology, Ageo Central General Hospital, Japan. k-abe@radiol.med.kyushu-u.ac.jp
Purpose:
The purpose of this study was to evaluate the reliability of left ventricular ejection fraction (LVEF) measured by quantitative gated SPECT (QGS). We compared the efficacy of LVEF assessment among Tc-99m tetrofosmin gated SPECT imaging, contrast left ventriculography (LVG), and first-pass radionuclide angiography (FP).
Patients:
One-hundred and seven patients with ischemic heart disease underwent QGS and LVG simultaneously within 3 months, and 92 of the 107 patients also underwent FP at the same time.
Results:
QGS progressively overestimated LVEF at the lower range of end-systolic volume (ESV), especially in patients with small hearts. Moreover, the QGS technique systemically tended to underestimate LVEF in comparison with LVG. However, linear regression analysis demonstrated a good correlation between the LVEF values measured by QGS and those measured by both LVG (p<0.0001) and FP (p<0.0001).
Conclusion:
Although QGS has a tendency to overestimate LVEF in patients with small hearts, and to systemically underestimate LVEF compared with LVG, this technique is still a reliable clinical tool for measurement of LVEF.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...