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Updated: Jul 9, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Information networks in the mammary gland
Lothar Hennighausen1, Gertraud W Robinson
1Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. lotharh@amb.niddk.nih.gov
Abstract:
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections.

