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Prolactin similar to ectopic pituitary isograft restores responsiveness in Snell dwarf mice
R Bouchon1, G Griebel, E Vogel
1Laboratoire de Psychophysiologie, URA-CNRS, Université Louis Pasteur, Strasbourg, France.
Neuroreport
|February 1, 1992
Abstract:
The effects of ovine prolactin (PRL) (2 x 5 IU a day) and an ectopic pituitary isograft on the responsiveness were examined using locomotor and exploratory activities as measures in PRL-growth-hormone-thyrotropin-deficient Snell dwarf mice (dw/dw). After 5 weeks of treatment, both PRL and the graft restored the two behavioural measures to normal levels. Results clearly demonstrate the involvement of PRL in global behavioural responsiveness and suggest a possible role for PRL in the changes induced by the graft.