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FHA domain-ligand interactions: importance of integrating chemical and biological approaches

Anjali Mahajan1, Chunhua Yuan, Brietta L Pike

  • 1Biophysics Program, The Ohio State University, Columbus, Ohio 43210, USA.

Journal of the American Chemical Society
|October 20, 2005
PubMed

Abstract:

Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.

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