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Updated: Jun 26, 2026

Bimolecular Fluorescence Complementation
Published on: April 15, 2011
FHA domain-ligand interactions: importance of integrating chemical and biological approaches
Anjali Mahajan1, Chunhua Yuan, Brietta L Pike
1Biophysics Program, The Ohio State University, Columbus, Ohio 43210, USA.
Abstract:
Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.
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