Related Experiment Videos
Vesicular mycosis fungoides
Mary Gantcheva1, Adriana Lalova, Valentina Broshtilova
1Department of Dermatology and Venerology, Faculty of Medicine, Medical University, 1 St Georgi Sofiisky street, BG-1431 Sofia, Bulgaria. mary_gant@yahoo.com
Summary
A rare, aggressive form of mycosis fungoides presented with widespread vesicles and erosions. This vesicular variant indicates a poor prognosis for patients with cutaneous T-cell lymphoma.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Mycosis fungoides is the most common type of cutaneous T-cell lymphoma.
- It typically follows an indolent course, but aggressive variants exist.
Observation:
- A 62-year-old patient presented with rapidly progressive mycosis fungoides.
- The patient exhibited numerous vesicles and erosions on the face, head, trunk, and limbs.
Findings:
- Histopathology revealed marked spongiosis and intraepidermal blisters.
- Atypical lymphocytes invading the epidermis were confirmed by immunohistochemistry.
- These findings are characteristic of the rare vesicular variant of mycosis fungoides.
Implications:
- The vesicular variant of mycosis fungoides is associated with a poor prognosis.
- Early recognition and aggressive management are crucial for patients with this rare subtype.
- Further research into targeted therapies for aggressive mycosis fungoides is warranted.