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Protection against ischaemia: the basis of acute stroke therapy
1Department of Neurology, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.
Current Opinion in Neurology and Neurosurgery
|February 1, 1992
Abstract:
The search for effective therapy of acute stroke, centres on the two strategies of restoring blood flow before ischaemia causes irreversible infarction, and moderation of the biochemical changes in ischaemic tissue that cause neuronal death. This review concentrates on the role of lactacidosis, calcium ions, free radicals, and excitatory neurotransmitters in the pathogenesis of neuronal death, and on the therapeutic possibilities in acute stroke emerging from studies in animal models.