Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunology of multiple sclerosis.

T Olsson1

  • 1Department of Neurology, Karolinska Institutet, Huddinge Hospital, Stockholm, Sweden.

Current Opinion in Neurology and Neurosurgery
|April 1, 1992
PubMed
Summary

Multiple sclerosis (MS) involves central nervous system (CNS) inflammation with increased T and B cells targeting myelin antigens. Further research is needed to understand the function and regulation of these autoimmune cells in MS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

All-cause mortality following a cancer diagnosis amongst multiple sclerosis patients: a Swedish population-based cohort study.

European journal of neurology·2015
Same author

Shift work influences multiple sclerosis risk.

Multiple sclerosis (Houndmills, Basingstoke, England)·2015
Same author

Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases.

Journal of internal medicine·2015
Same author

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2015
Same author

Obesity interacts with infectious mononucleosis in risk of multiple sclerosis.

European journal of neurology·2014
Same author

Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.

International journal of obesity (2005)·2014

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Cellular Immunology

Background:

  • Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS).
  • The CNS expresses major histocompatibility complex (MHC) class I and II antigens and lymphocyte adhesion molecules.
  • Immune cells within the CNS produce key effector molecules like interferon-gamma (IFN-γ) and tumor necrosis factor (TNF).

Purpose of the Study:

  • To discuss recent advancements in understanding the immunology of multiple sclerosis (MS).
  • To highlight the presence and role of immune cells and molecules within the CNS in MS pathogenesis.
  • To explore the evidence supporting myelin antigen-specific autoimmunity in MS.

Main Methods:

  • Review of current literature on MS immunology.
  • Analysis of the expression of MHC antigens and adhesion molecules in the CNS.
  • Identification of effector molecules produced by CNS-resident cells.
  • Assessment of T and B cell populations with specificity for myelin antigens in the CNS.

Main Results:

  • The central nervous system (CNS) in MS exhibits expression of major histocompatibility complex (MHC) antigens and lymphocyte adhesion molecules.
  • Immune cells within the CNS produce effector molecules such as interferon-gamma (IFN-γ) and tumor necrosis factor (TNF).
  • A significant quantitative increase of T and B cells specific for myelin antigens, enriched in the CNS, supports a role for autoimmunity, though not definitively proven.

Conclusions:

  • The immunological landscape of the CNS in MS involves antigen presentation and effector molecule production.
  • Myelin antigen-specific autoimmunity is implicated in MS, evidenced by increased specific T and B cells in the CNS.
  • Future research should focus on the functional capabilities and regulatory mechanisms of these myelin-specific immune cells in MS.

Related Experiment Videos