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Updated: Aug 15, 2026

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities
Published on: December 25, 2015
A novel industrial-level reactor with two dynamic changes of air for solid-state fermentation
Chen Hongzhang1, Xu Fujian, Tian Zhonghou
1State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080, China. chenhzh@yahoo.com
Abstract:
A novel industrial-level solid-state reactor (70 m3) with two dynamic changes of air was designed and has been put into operation successfully, in which the unite of virulence of Bacillus thuringiensis produced is maintained above 18,000 IU/mg. Two dynamic changes of air (including air pressure pulsation and internal circulation) in the fermentor can increase mass and heat transfers, as well as improve the porosity within the substrate. The reactor is novel and of significance in exploiting numerous socioeconomic advantages of solid-state fermentation.
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