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A novel industrial-level reactor with two dynamic changes of air for solid-state fermentation
Chen Hongzhang1, Xu Fujian, Tian Zhonghou
1State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080, China. chenhzh@yahoo.com
Journal of Bioscience and Bioengineering
|October 20, 2005
Summary
A new 70 m3 solid-state reactor enhances Bacillus thuringiensis production using dynamic air changes. This innovation boosts fermentation efficiency and yields high virulence, offering significant industrial advantages.
Area of Science:
- Biotechnology
- Industrial Microbiology
- Fermentation Engineering
Background:
- Solid-state fermentation (SSF) is crucial for producing various biomolecules.
- Scaling up SSF processes presents challenges in mass and heat transfer.
- Optimizing reactor design is key to improving SSF efficiency and yield.
Purpose of the Study:
- To design and operate a novel industrial-scale solid-state reactor.
- To enhance the production of Bacillus thuringiensis using improved fermentation conditions.
- To investigate the impact of dynamic air changes on SSF processes.
Main Methods:
- Development of a 70 m3 industrial-level solid-state reactor.
- Implementation of two dynamic air changes: air pressure pulsation and internal circulation.
- Monitoring of Bacillus thuringiensis virulence (IU/mg) during fermentation.
Main Results:
- Successful operation of the novel solid-state reactor.
- Maintained Bacillus thuringiensis virulence above 18,000 IU/mg.
- Dynamic air changes improved mass and heat transfer and substrate porosity.
Conclusions:
- The novel reactor design is effective for industrial-scale solid-state fermentation.
- Dynamic air management strategies enhance fermentation performance.
- This advancement offers significant socioeconomic benefits for SSF applications.