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Updated: Aug 15, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Enzymatic synthesis of sugar amino acid esters in organic solvents
Tatsuo Maruyama1, Shin-Ichiro Nagasawa, Masahiro Goto
1Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan.
Abstract:
The enzymatic synthesis of sugar amino acid esters in polar organic solvents was studied using surfactant-enzyme complexes, which were previously developed as a highly active biocatalyst in organic solvents. Of the several lipases and proteases tested, the surfactant-subtilisin complex exhibited the highest synthetic activity in pyridine. The amino acid was regioselectively introduced at the C-6 position of d-glucose and at the C-6' of maltose by the surfactant-subtilisin complex. This biocatalyst was found to effectively catalyze the synthesis of various sugar amino acid esters in a polar organic solvent.
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