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A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries
Published on: January 28, 2018
A bead-alignment device with a bead-sized microchamber on a rotating cylinder for fabrication of a miniaturized probe
Hideyuki Noda1, Masahiro Kaise, Yoshinobu Kohara
1Hitachi, Ltd., Central Research Laboratory 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan. noda-h@crl.hitachi.co.jp
Abstract:
We have developed a compact bead-alignment device with a bead-sized microchamber on a rotating cylinder. The cylinder fits inside a tube with bead-stock pipes containing different probe-conjugated beads and holes for bead-alignment capillaries. The cylinder rotates in the tube, and the microchamber transfers a single 100-microm-diameter bead from a pipe to one of the capillaries in 10 s. By using this process repeatedly, 'bead arrays', which are miniaturized DNA probe arrays in capillaries, were successfully fabricated.
