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Updated: Aug 15, 2026

Preparation of High-Quality Fermented Fish Product
Published on: August 23, 2019
Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish
Toshiaki Ichimura1, Jianen Hu, Duong Qua Aita
1Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. ichimura@ni.aist.go.jp
Abstract:
Angiotensin I-converting enzyme (ACE) inhibitory peptides, Ala-Pro, Lys-Pro, and Arg-Pro, were isolated from fermented fish sauce. Five other proline-containing dipeptides having weak ACE inhibitory activity were also isolated from the fermented fish sauce. Orally administered Lys-Pro showed a tendency to lower the blood pressure of spontaneously hypertensive rats. As fermented anchovy sauce also stimulated insulin secretion by cultured RINm5F insulinoma cells, the sauce may be useful as a source of biologically active substances.
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