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Updated: Aug 15, 2026

The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective
Published on: June 16, 2022
Toxicity of ionic liquids and organic solvents to lactic acid-producing bacteria
Michiaki Matsumoto1, Kenji Mochiduki, Kazuo Kondo
1Department of Chemical Engineering and Materials Science, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0321, Japan. mmatsumo@mail.doshisha.ac.jp
Abstract:
In situ extractive fermentation of lactic acid using organic solvents has already been extensively investigated. Now ionic liquids are emerging as alternative solvents for volatile organic compounds traditionally used in liquid-liquid extraction. In this study, we examine whether lactic acid producing-bacteria can grow in the presence of a second phase of imidazolium-based ionic liquids or organic solvents. The lactic acid producing-bacteria used in this study are sensitive to organic solvents having 1 < log P < 4. We found that Lactobacillus delbruekii subsp. lactis NRIC 1683 could grow in the presence of a second phase of imidazolium-based ionic liquids as well as in the absence of the ionic liquids.
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