Related Experiment Video
Updated: Aug 15, 2026

ROS Live Cell Imaging During Neuronal Development
Published on: February 9, 2021
A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins
Hisashi Muramatsu1, Hisaaki Mihara, Masaru Goto
1Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Abstract:
A new family of NAD(P)H-dependent oxidoreductases is now recognized as a protein family distinct from conventional Rossmann-fold proteins. Numerous putative proteins belonging to the family have been annotated as malate dehydrogenase (MDH) or lactate dehydrogenase (LDH) according to the previous classification as type-2 malate/L-lactate dehydrogenases. However, recent biochemical and genetic studies have revealed that the protein family consists of a wide variety of enzymes with unique catalytic activities other than MDH or LDH activity. Based on their sequence homologies and plausible functions, the family proteins can be grouped into eight clades. This classification would be useful for reliable functional annotation of the new family of NAD(P)H-dependent oxidoreductases.
Related Concept Videos
Redox Reactions
Redox Reactions
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
The Supercomplexes in the Crista Membrane
Structure of Porins
Role of Reduced Coenzymes NADH and FADH₂

