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Vesicoureteric reflux in sibships.
D T Uehling1, R E Vlach, R M Pauli
1Department of Surgery (Division of Urology), University of Wisconsin Medical School, Madison.
British Journal of Urology
|May 1, 1992
Summary
Familial vesicoureteric reflux (VUR) in siblings suggests autosomal dominant inheritance with incomplete penetrance. Urine analysis, culture, and ultrasound are recommended for screening affected family members.
Area of Science:
- Pediatric Nephrology
- Medical Genetics
- Urology
Background:
- Vesicoureteric reflux (VUR) is a common condition in children.
- Familial occurrence of VUR suggests a genetic component.
- Understanding the inheritance patterns of VUR is crucial for diagnosis and management.
Purpose of the Study:
- To present a family with a high incidence of VUR among siblings.
- To investigate the genetic basis of familial VUR.
- To recommend appropriate screening methods for at-risk individuals.
Main Methods:
- Case report of a family with VUR.
- Genetic analysis to determine inheritance patterns.
- Review of diagnostic methods for VUR screening.
Main Results:
- Four out of six siblings presented with VUR.
- No VUR was observed in preceding or succeeding generations.
- Genetic analysis indicated autosomal dominant inheritance with incomplete penetrance.
Conclusions:
- Familial VUR often results from autosomal dominant genes with incomplete penetrance.
- Screening sibships for VUR using urine analysis, culture, and ultrasound is recommended.
- Early detection through genetic and clinical evaluation can improve VUR management.