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Updated: Aug 15, 2026
A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating
Published on: July 8, 2016
[Study of biocompatibility of polybutylcyanoacrylate nanoparticles]
Xi-xiao Yang1, Jan-hai Chen, Dan Guo
1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yaxx@263.net
Objective:
To evaluate the biocompatibility of polybutylcyanoacrylate nanoparticles (PBCA-NP) manufactured by emulsion polymerization technique.
Methods:
MTT assay was performed for evaluation of the cytotoxicity of PBCA-NP (e.g. cell proliferation and hemolytic test) experiments of long-term subcutaneous implantation and implantation in the muscular tissues of PBCA-NP was conducted in rabbits to observe the inflammatory reactions due to the implantation.
Results:
No obvious cytotoxicity or hemolytic reactions were observed (with the hemolytic rate at different concentrations of PBCA-NP(5%). Three months after PBCA-NP implantation, obvious lymphocyte infiltration was not observed in the tissues around the implants which underwent gradual degradation.
Conclusion:
PBCA-NP possesses good biocompatibility.
