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Updated: Jul 28, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Effects of levonorgestrel-releasing intrauterine system on serum lipids and hepatic function]
1Department of Obstetrics and Gynecology, Xiaolan People's Hospital, Zhongshan 528415, China. hsm@xlrmyy.com
Objective:
To assess the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and hepatic function.
Methods:
Blood samples of 35 cases receiving LNG-IUS were collected and determined for serum lipids and hepatic functions.
Results:
Six months after insertions, HDL-C and ApoA were increased significantly, while LDL-C and ApoB decreased significantly. TG and TC levels were decreased at the 6th months and showed significant difference till the end of one year. TG/HDL-C and LDL-C/HDL-C ratios were increased and Apo A/ApoB ratio decreased significantly. The indices of hepatic function varied in the normal ranges, while Glb were decreased significantly after one year.
Conclusion:
LNG-IUS is an effective therapy without obvious adverse effect on lipid metabolism and hepatic function.
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