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Increased pulse wave velocity in subclinical hypothyroidism
Toshiki Nagasaki1, Masaaki Inaba, Yasuro Kumeda
1Department of Metabolism, Endocrinology, and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
The Journal of Clinical Endocrinology and Metabolism
|October 20, 2005
Summary
Subclinical hypothyroidism is linked to higher arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV). Increased diastolic blood pressure (DBP) appears to be a key factor driving this arterial stiffening in affected individuals.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Biology
Background:
- Subclinical hypothyroidism affects 5-15% of the population, increasing cardiovascular disease (CVD) risk.
- Brachial-ankle pulse wave velocity (baPWV) measures arterial stiffness and predicts coronary artery disease.
- Arterial stiffening is a significant contributor to cardiovascular morbidity.
Purpose of the Study:
- To investigate the relationship between subclinical hypothyroidism and brachial-ankle pulse wave velocity (baPWV).
- To determine if subclinical hypothyroidism is associated with enhanced arterial stiffness.
- To explore potential contributing factors to arterial stiffening in subclinical hypothyroidism.
Main Methods:
- baPWV was measured in 50 patients with subclinical hypothyroidism and 50 healthy controls.
- Diastolic blood pressure (DBP) and other cardiovascular parameters were assessed.
- Correlation and regression analyses were performed to identify associations.
Main Results:
- Subclinical hypothyroid patients exhibited significantly higher baPWV and DBP compared to controls.
- baPWV correlated positively with age, systolic, diastolic, and pulse pressure.
- DBP showed a significant and independent association with baPWV in both groups.
Conclusions:
- Subclinical hypothyroidism is associated with increased arterial stiffness (baPWV) and elevated DBP.
- Elevated DBP is suggested as a primary factor contributing to arterial stiffening in subclinical hypothyroidism.
- These findings highlight the cardiovascular implications of subclinical hypothyroidism.