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Related Experiment Videos

Chronic nonpulsatile blood flow is compatible with normal end-organ function: implications for LVAD development.

Satoshi Saito1, Tomohiro Nishinaka

  • 1Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. ssaitos@hij.twmu.ac.jp

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|October 20, 2005
PubMed
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Continuous-flow left ventricular assist devices (LVADs) offer user-friendly options, and evidence suggests chronic nonpulsatile circulation is safe. Reduced pulse pressure from these pumps maintains end-organ function and may impact arterial wall morphology.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Science
  • Medical Device Technology

Background:

  • Advancements in blood pump technology have led to user-friendly continuous-flow left ventricular assist devices (LVADs).
  • Uncertainty remains regarding the safety and long-term effects of chronic nonpulsatile circulation generated by these devices.

Purpose of the Study:

  • To evaluate the safety and implications of chronic nonpulsatile circulation from modern blood pumps.
  • To explore the impact of reduced pulse pressure on end-organ function and arterial wall morphology.

Main Methods:

  • Review of recent experimental and clinical evidence concerning nonpulsatile blood flow.
  • Analysis of data on end-organ function and arterial wall changes in patients with LVADs.

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Main Results:

  • Evidence suggests that pulse pressure is not essential for blood pump function.
  • End-organ function is well-maintained with nonpulsatile LVAD systems.
  • Reduced pulse pressure may alter aortic wall morphology, with potential therapeutic implications for arterial pathology.

Conclusions:

  • Chronic nonpulsatile circulation with continuous-flow LVADs appears safe and feasible for long-term use.
  • The ability to modify arterial wall morphology through reduced pulse pressure presents new avenues for treating arterial diseases.