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DADLE induces a reversible hibernation-like state in HeLa cells

Lorella Vecchio1, Cristiana Soldani, Maria Grazia Bottone

  • 1Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale, Università di Pavia and Istituto di Genetica Molecolare del CNR, Piazza Botta 10, 27100, Pavia, Italy.

Histochemistry and Cell Biology
|October 20, 2005
PubMed
Summary

[D-Ala(2)-D-Leu(5)-Enkephalin] (DADLE) peptide treatment temporarily reduces cell transcription and proliferation by affecting RNA polymerase and splicing factors. Cell function gradually resumes upon DADLE removal, indicating reversible metabolic regulation.

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