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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
Amniotic fluid infection syndrome and neonatal mortality caused by Eikenella corrodens
Stefan Kostadinov1, Halit Pinar
1Division of Perinatal Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA. skostadinov@wihri.org
Abstract:
Different microorganisms not commonly found in the female genital tract have been implicated as causative agents for amniotic fluid infections. Eikenella corrodens is part of the normal flora in the human oral cavity and upper respiratory tract. It is most commonly found in the clinical setting of polymicrobial infections involving human bite wounds, head and neck infections, and periodontitis. On rare occasions, E. corrodens has been reported as a cause of gynecologic infections. There are only 3 reports of documented E. corrodens chorioamnionitis of the placenta resulting in preterm labor, one of which is associated with early neonatal demise. We report a case of preterm delivery of twin infants at 23 weeks of gestation with documented E. corrodens infection in 1 twin who was not resuscitated.
Insights
Eikenella corrodens, a bacterium from the oral cavity, can cause rare amniotic fluid infections leading to preterm birth. This case highlights the potential risks of this pathogen in pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Microbiology
Background:
- Amniotic fluid infections can arise from unusual microorganisms.
- Eikenella corrodens is typically found in the oral and respiratory tracts, associated with polymicrobial infections.
- Gynecologic infections caused by E. corrodens are infrequent.
Observation:
- This report details a rare case of Eikenella corrodens chorioamnionitis.
- The infection occurred in a twin pregnancy resulting in preterm delivery at 23 weeks' gestation.
- One twin infant had documented E. corrodens infection and was not resuscitated.
Findings:
- Eikenella corrodens can be a causative agent of chorioamnionitis and subsequent preterm labor.
- This case adds to the limited reports of E. corrodens-associated adverse pregnancy outcomes.
- The study underscores the potential severity of this pathogen in obstetric settings.
Implications:
- Clinicians should consider Eikenella corrodens in cases of unexplained preterm labor and chorioamnionitis.
- Further research is needed to understand the pathogenesis and management of E. corrodens infections during pregnancy.
- Early recognition and appropriate treatment may improve outcomes for both mother and neonate.
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