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Related Experiment Videos

Assisted hatching on assisted conception (IVF & ICSI).

M M W Seif1, E C O Edi-Osagie, C Farquhar

  • 1University of Manchester @ St Mary's Hospital, Academic Unit of Obstetrics, Gynaecology & Reproductive Health, Whitworth Park, Manchester, UK M13 0JH. mwseif@manchester.ac.uk

The Cochrane Database of Systematic Reviews
|October 20, 2005
PubMed
Summary
This summary is machine-generated.

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Assisted hatching (AH) significantly increases clinical pregnancy rates but does not improve live birth rates. The procedure raises concerns about multiple pregnancies, and evidence is insufficient to recommend its routine use.

Area of Science:

  • Reproductive Medicine
  • Infertility Treatments
  • Embryology

Background:

  • Implantation failure can stem from blastocyst hatching difficulties, potentially exacerbated by in vitro culture or maternal age.
  • Assisted hatching (AH), involving artificial disruption of the zona pellucida, is explored to enhance assisted conception success rates.

Purpose of the Study:

  • To evaluate the efficacy of assisted hatching (AH) in facilitating live births and clinical pregnancies.
  • To assess the impact of AH on adverse outcomes, including multiple pregnancies and miscarriage rates.

Main Methods:

  • Systematic review and meta-analysis of 23 randomized controlled trials (RCTs) involving 2668 women.
  • Included trials compared mechanical, chemical, or laser disruption of the zona pellucida (AH) against no AH.

Related Experiment Videos

  • Outcomes analyzed included live birth, clinical pregnancy, implantation rates, miscarriage, and multiple pregnancy.

    • Main Results:

    • Assisted hatching (AH) significantly increased clinical pregnancy rates (OR 1.33, 95% CI 1.12 to 1.57).
    • No significant difference was observed in live birth rates (OR 1.19, 95% CI 0.81 to 1.73) or miscarriage rates.
    • A significant increase in multiple pregnancy rates was noted in the AH group (OR 1.83, 95% CI 1.19 to 2.83).

    Conclusions:

    • While AH improves clinical pregnancy rates, evidence for enhanced live birth rates remains insufficient.
    • The observed increase in multiple pregnancies warrants caution; single embryo transfer policies may mitigate this risk.
    • Current evidence does not support the routine recommendation of assisted hatching.