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Related Experiment Videos

Trimetazidine for stable angina.

A Ciapponi1, R Pizarro, J Harrison

  • 1Hospital Italiano de Buenos Aires, Division of Family and Preventive Medicine, Peron 4272, Buenos Aires, Argentina 1199. agustin.ciapponi@hospitalitaliano.org.ar

The Cochrane Database of Systematic Reviews
|October 20, 2005
PubMed
Summary
This summary is machine-generated.

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Trimetazidine effectively reduces angina symptoms and nitroglycerin use compared to placebo. This anti-anginal drug may also lead to fewer adverse event dropouts, but more research is needed.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Standard treatments for stable angina include nitrates, beta-blockers, and calcium channel blockers, often used in combination.
  • Combinations may lead to adverse effects or contraindications.
  • Alternative treatments are needed, especially in developing countries where revascularization is inaccessible.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of trimetazidine for stable angina.

Main Methods:

  • A systematic review of randomized controlled trials was conducted.
  • Searches included Cochrane Central Register, MEDLINE, EMBASE, LILACS, and SCISEARCH up to October 2003.
  • Two reviewers assessed trial quality and extracted data.

Main Results:

Related Experiment Videos

  • Twenty-three studies with 1378 patients were included.
  • Trimetazidine significantly reduced weekly angina attacks and nitroglycerin consumption compared to placebo.
  • Exercise tolerance improved, but data on mortality and cardiovascular events were limited.

Conclusions:

  • Trimetazidine demonstrates efficacy in treating stable angina, outperforming placebo.
  • The drug appears to have a favorable side effect profile, potentially causing fewer dropouts.
  • Further large-scale, long-term trials are necessary to define trimetazidine's role in clinical practice.