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Related Experiment Videos

Laser photocoagulation for choroidal neovascularisation in pathologic myopia.

G Virgili1, F Menchini

  • 1University of Florence, Eye Clinic II, Department Oto-Neuro-Ophthalmological Surgical Sciences, Via le Morgagni 85, Florence, Italy 50134. gianni.virgili@unifi.it

The Cochrane Database of Systematic Reviews
|October 20, 2005
PubMed
Summary

Laser photocoagulation for pathologic myopia-associated choroidal neovascularisation (CNV) lacks established effectiveness. While one study suggested short-term benefits for non-subfoveal CNV, potential bias and long-term complications like scar enlargement warrant caution.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Interventions

Background:

  • Pathologic myopia, defined by -6 diopters or higher spectacle correction, frequently leads to visual loss due to choroidal neovascularisation (CNV).
  • CNV in myopic macular degeneration can cause fibrotic scarring and central vision loss.
  • This review focuses on laser photocoagulation treatments for CNV in pathologic myopia.

Purpose of the Study:

  • To evaluate the efficacy of laser photocoagulation for treating choroidal neovascularisation (CNV) in pathologic myopia.
  • To compare the outcomes of different laser photocoagulation techniques.

Main Methods:

  • Systematic search of multiple databases including CENTRAL, MEDLINE, EMBASE, and LILACS.
  • Inclusion of randomized controlled trials comparing laser photocoagulation with observation or different laser techniques for myopic CNV (-6D or higher).

Related Experiment Videos

  • Independent assessment of search results by two authors for eligibility.

    • Main Results:

    • Two studies were included, focusing on CNV located at least 100 microns from the foveal center.
    • One study showed 16/35 participants on photocoagulation had worse vision (20/100+) versus 31/35 on observation after 6-48 months.
    • A second study on laser wavelengths found 2/9 eyes (577 nm), 3/9 (590 nm), and 3/9 (620 nm) lost two lines of vision within 3-17 months; interpretation was limited by differing follow-up times.

    Conclusions:

    • The effectiveness of laser photocoagulation for myopic CNV remains unproven despite its historical use.
    • A small study indicated potential short-term benefits for non-subfoveal CNV, but results were possibly biased.
    • Observational data suggest laser-induced scar enlargement is a potential long-term vision-threatening complication, even without CNV recurrence.