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Resetting the immune system in immune thrombocytopenic purpura: immunoablative strategies

Patrick F Fogarty1, Cynthia E Dunbar

  • 1Department of Laboratory Medicine, Hematology Service, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508, USA. fogartyp@nhlbi.nih.gov

Clinical Advances in Hematology & Oncology : H&O
|October 21, 2005
PubMed

As is the case with many chronic disorders, the toxicity of treatment for refractory immune thrombocytopenic purpura (ITP) often rivals that of the disease itself. In recent years, attention has turned to strategies designed to permanently rectify the abnormal immune milieu that has permitted the production of autoreactive antibodies, thereby averting chronic administration of morbidity-causing immunosuppressive medications. Approaches that will be discussed include conventional chemotherapy, high-dose chemotherapy with and without autologous stem cell support, and allogeneic transplantation.

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