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Updated: Aug 15, 2026

A Multi-hole Cryovial Eliminates Freezing Artifacts when Muscle Tissues are Directly Immersed in Liquid Nitrogen
06:42

A Multi-hole Cryovial Eliminates Freezing Artifacts when Muscle Tissues are Directly Immersed in Liquid Nitrogen

Published on: April 6, 2017

Dual cryogenic fixation for mechanical testing of soft musculoskeletal tissues

Nanthan Ramachandran1, Yoichi Koike, Philippe Poitras

  • 1Bone and Joint Research Laboratory, University of Ottawa, 451 Smyth Road, Rm. 1321, Ottawa, ON K1H 8M5 Canada. nanthanr@uottawa.ca

IEEE Transactions on Bio-Medical Engineering
|October 21, 2005
PubMed

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...