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Updated: Jul 23, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[A girl with breath-holding spells and anaemia, treated with iron supplementation]
D Mul1, L N van Veen, N van der Lely
1Reinier de GraafGasthuis, afd. Kindergeneeskunde, Delft. d.mul@erasmusmc.nl
Insights
Iron supplementation effectively treated breath-holding spells in a young child diagnosed with anemia. This intervention significantly reduced spell frequency and severity, leading to their complete resolution.
Area of Science:
- Pediatrics
- Hematology
- Neurology
Background:
- Breath-holding spells are common in young children.
- Anemia is a potential comorbidity that requires investigation.
Observation:
- A 1.5-year-old girl presented with frequent breath-holding spells.
- The patient was also diagnosed with anemia.
Findings:
- Iron supplementation therapy led to a marked reduction in the frequency and severity of breath-holding spells.
- The spells completely resolved following iron supplementation.
Implications:
- Iron deficiency anemia may be a contributing factor to breath-holding spells.
- Iron supplementation is a potentially effective treatment for breath-holding spells in anemic children.
- Further research is needed to elucidate the pathophysiological link between anemia and breath-holding spells.
Abstract:
A girl aged 1.5 years was presented because of frequent breath-holding spells. Anaemia was also diagnosed. Iron supplementation reduced the frequency and severity of the spells until they fully disappeared. The pathophysiological relationship between breath-holding spells and anaemia has not been clarified, but iron supplementation appears to be effective in many patients.
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