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Related Experiment Videos

Nitric oxide involves in carnosine-induced hyperactivity in chicks.

Shozo Tomonaga1, Tetsuya Tachibana, Hirokazu Takahashi

  • 1Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.

European Journal of Pharmacology
|October 21, 2005
PubMed
Summary
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Carnosine causes hyperactivity in chicks, potentially through nitric oxide (NO) generation. This effect is blocked by constitutive nitric oxide synthase (cNOS) inhibitors, suggesting cNOS involvement in carnosine

Area of Science:

  • Neuroscience
  • Biochemistry
  • Animal Behavior

Background:

  • Carnosine is a dipeptide with proposed roles as a neurotransmitter and in neuron-glia interactions.
  • Previous studies confirmed carnosine administration induces hyperactivity in chicks.

Purpose of the Study:

  • To investigate the role of nitric oxide synthase (NOS) in carnosine-induced hyperactivity.
  • To determine if constitutive NOS (cNOS) or inducible NOS (iNOS) mediates this effect.

Main Methods:

  • Chicks received intracerebroventricular (i.c.v.) injections of carnosine.
  • Carnosine co-administration with non-selective NOS inhibitor (N(G)-nitro-L-arginine methyl ester HCl) or selective iNOS inhibitor (L-N(6)-(1-iminoethyl) lysine HCl).
  • Effects on hyperactivity were assessed and compared with inactive isomer controls.

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Main Results:

  • Carnosine-induced hyperactivity was dose-dependently attenuated by the non-selective NOS inhibitor.
  • The inactive isomer of the NOS inhibitor did not affect carnosine-induced hyperactivity.
  • Selective inhibition of iNOS did not alter carnosine-induced hyperactivity.

Conclusions:

  • Carnosine-induced hyperactivity in chicks is likely mediated by constitutive NOS (cNOS), not iNOS.
  • Central carnosine may regulate brain function and behavior via NO generation through cNOS in chicks.