Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune interactions at the maternal-fetal interface.

Margaret G Petroff1

  • 1Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. mpetroff@kumc.edu

Journal of Reproductive Immunology
|October 21, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of antibiotics on membrane vesicle production in Group B <i>Streptococcus</i>.

Microbiology spectrum·2025
Same author

Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.

bioRxiv : the preprint server for biology·2025
Same author

Group B Streptococcal Membrane Vesicles Induce Proinflammatory Cytokine Production and Are Sensed in an NLRP3 Inflammasome-Dependent Mechanism in a Human Macrophage-like Cell Line.

ACS infectious diseases·2025
Same author

Changes in thyroid hormone concentrations over time in dogs with autoimmune thyroiditis.

American journal of veterinary research·2024
Same author

Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.

Scientific reports·2022
Same journal

Successful live birth following immunomodulatory therapy in a patient with multiple recurrent pregnancy loss and massive perivillous fibrinoid deposition.

Journal of reproductive immunology·2026
Same journal

Circulating neutrophil extracellular traps and deoxyribonuclease in gestational diabetes mellitus.

Journal of reproductive immunology·2026
Same journal

Association between endometriosis and chronic endometritis: A retrospective cross-sectional study.

Journal of reproductive immunology·2026
Same journal

Inhibition of NHE1 induces trophoblast cell senescence via ADGRG6 mediated by CXCL8.

Journal of reproductive immunology·2026
Same journal

Combined spermidine and umbilical cord mesenchymal stem cell therapy repairs endometrial injury in mice via IL-10/Treg-Dependent immune microenvironment modulation.

Journal of reproductive immunology·2026
Same journal

Vaginal versus cervical types of visible fetal membranes in cervical insufficiency: Clinical characteristics and pathophysiology.

Journal of reproductive immunology·2026
See all related articles

Maternal immune tolerance during pregnancy involves suppressing T cells that recognize fetal antigens. Key factors like indoleamine-2,3-dioxygenase and B7-H1 protein are crucial for fetal survival in allogeneic pregnancies.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Genetics

Background:

  • Maternal T cells normally recognize and react against fetal alloantigens.
  • Successful allogeneic pregnancy requires maternal immune tolerance to prevent rejection of the semi-allogeneic fetus.

Purpose of the Study:

  • To review the current understanding of mechanisms responsible for maternal lymphocyte suppression during allogeneic pregnancy.
  • To identify critical factors involved in maintaining immune tolerance to the fetus.

Main Methods:

  • Review of existing literature on murine allogeneic pregnancy models.
  • Analysis of identified factors and their roles in immune suppression.

Main Results:

  • Indoleamine-2,3-dioxygenase and B7-H1 protein are essential for fetal survival.

Related Experiment Videos

  • These factors may regulate maternal T regulatory cells, vital for successful pregnancy.
  • Trophoblast, FasL, and human class Ib HLA molecules also contribute to immune protection.

    • Conclusions:

    • Specific mechanisms of maternal lymphocyte suppression are critical for protecting the fetal allograft.
    • Further research is needed to clarify the intersecting functions of identified factors in immune tolerance.