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Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial
Peiman Haddad1, Bita Kalaghchi, Farnaz Amouzegar-Hashemi
1Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. haddad@sina.tums.ac.ir
Abstract:
We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm(2) after treatment (P<0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm(2) (P<0.001). Pentoxifylline-vitamin E combination improved radiation-induced fibrosis.