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[Renal involvement in ankylosing spondylitis: concerning 210 cases]
C Ben Taarit1, H Ajlani, F Ben Moussa
1Unité de rhumatologie, laboratoire de pathologie rénale santé 02, service de médecine interne A, hôpital Charles-Nicolle, Tunis, Tunisie.
La Revue De Medecine Interne
|October 21, 2005
Summary
Kidney disease affects 13.3% of ankylosing spondylitis patients, with secondary amyloidosis and nephrolithiasis being common. Active investigation for renal involvement is recommended in ankylosing spondylitis management.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Context:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- Renal involvement can be a serious complication of AS, impacting patient prognosis.
- Understanding the spectrum of kidney diseases in AS is crucial for timely diagnosis and management.
Purpose:
- To delineate the epidemiological, clinical, biological, and histological characteristics of renal diseases in ankylosing spondylitis.
- To identify the prevalence and types of kidney abnormalities in a cohort of AS patients.
- To highlight unusual presentations of renal involvement in AS.
Summary:
- A retrospective review of 210 ankylosing spondylitis patients identified renal involvement in 13.3% (28 cases).
- Common manifestations included hematuria, proteinuria, nephrotic syndrome, and decreased renal function.
- Secondary renal amyloidosis and nephrolithiasis were the most frequent causes, followed by IgA nephropathy.
Impact:
- The findings underscore the significant prevalence of renal abnormalities in ankylosing spondylitis.
- This study emphasizes the necessity for routine screening and active investigation of renal involvement in AS patients.
- Early detection and management of kidney disease can potentially improve outcomes for individuals with ankylosing spondylitis.