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24-hour efficacy of once-daily diltiazem in essential hypertension

B M Massie1, E Der, T S Herman

  • 1University of California, San Francisco.

Clinical Cardiology
|May 1, 1992
PubMed

Insights

This study shows that a new once-daily diltiazem hydrochloride extended-release formulation (diltiazem CD) effectively lowers blood pressure in patients with essential hypertension over a 24-hour period.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Essential hypertension is a widespread condition requiring effective long-term management.
  • Diltiazem hydrochloride is a calcium channel blocker used to treat hypertension.
  • Evaluating new formulations for improved patient compliance and sustained efficacy is crucial.

Purpose of the Study:

  • To assess the safety and effectiveness of a novel once-daily diltiazem hydrochloride extended-release formulation (diltiazem CD).
  • To determine if diltiazem CD provides 24-hour blood pressure control in patients with essential hypertension.

Main Methods:

  • A randomized, placebo-controlled trial involving 127 patients with essential hypertension.
  • Patients received either diltiazem CD (n=61) or placebo (n=66), with dose titration up to 360 mg/day.
  • Ambulatory blood pressure monitoring was used in a subset of patients to evaluate 24-hour efficacy.

Main Results:

  • Diltiazem CD significantly reduced supine systolic blood pressure (SBP) by -8.4 mmHg and diastolic blood pressure (DBP) by -8.6 mmHg (p<0.0075).
  • Heart rate remained largely unchanged, indicating a favorable safety profile.
  • Sixty-nine percent of patients achieved a clinical response, and 24-hour blood pressure control was demonstrated.

Conclusions:

  • Once-daily diltiazem CD is a safe and effective treatment for essential hypertension.
  • The formulation provides sustained 24-hour blood pressure reduction, supporting its use for improved patient adherence.

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