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Related Experiment Videos

Cystatin C and subclinical brain infarction.

Stephen L Seliger1, W T Longstreth, Ronit Katz

  • 1Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA. sseliger@medicine.umaryland.edu

Journal of the American Society of Nephrology : JASN
|October 21, 2005
PubMed
Summary

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Cystatin C (CysC) is a better indicator than serum creatinine (SCr) for predicting subclinical brain infarcts (SBI) in older adults. This study highlights CysC

Area of Science:

  • Gerontology
  • Nephrology
  • Neurology
  • Biomarkers

Background:

  • Subclinical brain infarcts (SBI) are prevalent in the elderly, linked to cognitive decline.
  • Renal impairment accelerates cerebrovascular disease, increasing stroke risk.
  • Previous studies on renal function and SBI were limited by creatinine's inaccuracy.

Purpose of the Study:

  • To investigate the association between renal function markers and SBI in older adults.
  • To compare the utility of serum creatinine (SCr) and cystatin C (CysC) in predicting SBI.
  • To determine if CysC offers a more accurate assessment of renal function's impact on SBI.

Main Methods:

  • Cross-sectional study using data from the Cardiovascular Health Study.

Related Experiment Videos

  • Measured serum creatinine (SCr) and cystatin C (CysC) in 2784 older adults.
  • Utilized logistic regression to analyze associations between renal markers (1/SCr, 1/CysC) and SBI detected via MRI.

    • Main Results:

    • Subclinical brain infarcts (SBI) were present in 28.7% of participants.
    • Cystatin C (CysC) showed a linear association with SBI (OR 1.20 per SD decrement).
    • Serum creatinine (SCr) did not show a significant linear association, but suggested a U-shaped relationship.

    Conclusions:

    • Cystatin C (CysC) is a stronger and more direct predictor of subclinical brain infarcts (SBI) in the elderly compared to serum creatinine (SCr).
    • CysC provides a more accurate assessment of renal function's role in cerebrovascular changes.
    • These findings suggest CysC may be a valuable biomarker for identifying elderly individuals at higher risk for SBI.