Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microbubbles: pathophysiology and clinical implications.

Michal Barak1, Yeshayahu Katz

  • 1Department of Anesthesiology, Rambam Medical Center, Haifa, Israel.

Chest
|October 21, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior.

Translational psychiatry·2021
Same author

Purifying selection of long dsRNA is the first line of defense against false activation of innate immunity.

Genome biology·2020
Same author

Differential lung ventilation for increased oxygenation during one lung ventilation for video assisted lung surgery.

Journal of cardiothoracic surgery·2019
Same author

The Role of the Anesthesiologist during Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Tremor: A Single-Center Experience.

Parkinson's disease·2018
Same author

Pre-reproductive stress and fluoxetine treatment in rats affect offspring A-to-I RNA editing, gene expression and social behavior.

Environmental epigenetics·2018
Same author

A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations.

BMC genomics·2018

Microbubbles, often overlooked consequences of medical procedures, can cause significant tissue damage by obstructing blood flow. This review highlights their pathophysiology, clinical impact, and strategies for management.

Area of Science:

  • Cardiovascular Research
  • Pulmonary Medicine
  • Medical Device Technology

Background:

  • Gas embolism is a recognized complication of invasive procedures.
  • The clinical significance of microemboli (microbubbles) is frequently underestimated in practice.
  • Microbubbles can arise from extracorporeal devices or endogenous sources.

Purpose of the Study:

  • To review the pathophysiology and clinical consequences of microbubbles.
  • To present evidence of microbubble-induced detrimental effects from animal and human studies.
  • To discuss the detection, prevention, and treatment of microbubble-related complications.

Main Methods:

  • Literature review of existing data on microemboli.
  • Analysis of studies investigating microbubble effects in animal models.

Related Experiment Videos

  • Examination of clinical evidence from human studies.

    • Main Results:

    • Microbubbles obstruct capillaries, leading to ischemia, inflammation, and complement activation.
    • Platelet aggregation and clot formation exacerbate microcirculatory obstruction and tissue damage.
    • Detrimental biological and clinical effects are documented in various organs, primarily the lungs.

    Conclusions:

    • Microbubbles pose a significant, underrecognized threat in clinical practice.
    • Effective management strategies for microbubbles are crucial.
    • Further research and clinical vigilance are needed for detection, prevention, and treatment.