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Updated: Aug 15, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Mutation in IRO1 tightly linked with URA3 gene reduces virulence of Candida albicans
Hiroji Chibana1, Jun Uno, Tamaki Cho
1Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan. chibana@faculty.chiba-u.jp
Microbiology and Immunology
|October 21, 2005
Abstract:
Gene deletion in the pathogenic fungus Candida albicans has relied heavily on a URA3 cassette and a recipient delta ura3 strain CAI4. The IRO1 gene adjacent to URA3 was inadvertently deleted during construction of CAI4. We report here that a mutation in IRO1 reduces virulence of C. albicans.
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