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[Paraneoplastic limbic encephalitis associated with epidermoid lung carcinoma]
C Dabbeche1, D Guyon, F Loubes-Lacroix
1Service de Neuroradiologie diagnostique et thérapeutique, Hôpital de Rangueil, 1, Avenue Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France.
Journal of Neuroradiology = Journal De Neuroradiologie
|October 21, 2005
Summary
Paraneoplastic limbic encephalitis, a rare condition, can be linked to lung cancer. This case highlights neurological symptoms associated with epidermoid lung carcinoma, improving after tumor treatment.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune disorder.
- It is most frequently associated with small cell lung cancer.
- PLE presents with neurological symptoms due to immune response against the tumor.
Observation:
- A 54-year-old man presented with status epilepticus, cognitive dysfunction, and short-term memory loss.
- Initial CT scans were normal.
- MRI revealed temporolimbic region hyperintensities on T2WI and FLAIR sequences.
Findings:
- The patient's symptoms were associated with an epidermoid lung carcinoma.
- Neuroimaging confirmed limbic system involvement.
- Neurological improvement was observed following treatment of the primary lung tumor.
Implications:
- This case expands the known oncological associations of PLE beyond small cell lung cancer.
- Early diagnosis and treatment of the underlying malignancy are crucial for neurological recovery.
- Highlights the importance of neuroimaging in diagnosing PLE.