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Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult
Published on: February 23, 2012
The diameters of common carotid artery and its branches in newborns
Umit S Sehirli1, A Yalin, C M Tulay
1Department of Anatomy, Marmara University School of Medicine, 34668 Haydarpasa, Istanbul, Turkey. usehirli@marmara.edu.tr
Insights
This study measured common carotid artery (CCA) and its branches (ICA, ECA) in newborns. Results show ratios align with optimal values for preventing atherosclerosis, crucial for early cardiovascular health.
Area of Science:
- Anatomy
- Vascular Biology
- Pediatric Medicine
Background:
- The common carotid artery (CCA) bifurcation is clinically significant for interventions and atherosclerosis.
- While adult carotid artery dimensions are studied, newborn data is scarce.
- Atherosclerosis begins early, making neonatal anatomy crucial.
Purpose of the Study:
- To determine the anatomical dimensions of the CCA and its branches (internal carotid artery - ICA, external carotid artery - ECA) in newborns.
- To calculate key arterial ratios and compare them to optimal values for vascular health.
- To identify potential sex or side-based differences in neonatal carotid artery anatomy.
Main Methods:
- Dissection of 20 fixed newborn cadavers (11 male, 9 female).
- Measurement of internal diameters of CCA, ICA, and ECA using light microscopy.
- Calculation of ECA/CCA, ICA/CCA, ICA/ECA, and outflow to inflow area ratios.
Main Results:
- The mean outflow to inflow area ratio was 1.14 ± 0.28, closely matching the optimal ratio of 1.15.
- Calculated ratios were: ECA/CCA (0.78 ± 0.12), ICA/CCA (0.71 ± 0.13), and ICA/ECA (0.93 ± 0.16).
- No statistically significant differences were found between sexes or sides.
Conclusions:
- Neonatal carotid artery dimensions and ratios are consistent with optimal values for preventing early atherosclerotic changes.
- These findings provide essential anatomical data for the newborn period, aiding in understanding early vascular development and disease.
- The study highlights the importance of early anatomical knowledge for pediatric vascular health.
Abstract:
The common carotid artery (CCA) bifurcation is of clinical importance due to its vascular access site for intravascular intervention. Additionally, it is also one of the most common sites of atherosclerotic plaque formation. There are numerous studies on the diameters of CCA, internal carotid artery (ICA), and external carotid artery (ECA) in adults, but few studies on newborns. Cadaver and angiographic studies have shown dimensional variations in the carotid arteries within/between individuals and also between different sexes. It is well known that the initial lesions of atherosclerosis begin very early in fetal life. Therefore, it is important to know the anatomical details of the CCA and its branches. In the present study, the neck regions of 20 (11 males and 9 females) fixed newborn cadavers were dissected. The CCAs were cut below the bulb of the carotid bifurcation further; ICA and ECA were cut above the bulb of the carotid bifurcation. The internal diameters of the CCA, ICA, and ECA were measured using a light microscopy. ECA/CCA, ICA/CCA, ICA/ECA ratios, and outflow to inflow area ratio were calculated. The mean outflow to inflow area ratio was 1.14+/-0.28. Our results highly correlated with the defined optimal ratio (1.15). The ECA/CCA, ICA/CCA, and ICA/ECA ratios were 0.78+/-0.12, 0.71+/-0.13, and 0.93+/-0.16, respectively. There were no statistically significant differences between male and female and also between right and left sides. These findings are of importance in understanding the anatomy of carotid artery during newborn period.
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