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Related Experiment Videos

Lung density and lung mass in emphysema.

H Guenard1, M H Diallo, F Laurent

  • 1Service d'Exploration Fonctionnelle Respiratoire, Hopital Pellegrin, Bordeaux, France.

Chest
|July 1, 1992
PubMed
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Emphysema patients often have normal or increased lung mass, contrary to expectations. This finding suggests chronic inflammation may lead to new tissue synthesis in the lungs.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging

Background:

  • Emphysema diagnosis relies on lung density (dm) and volume (VLx) from CT scans.
  • Overdistention in emphysema can make dm analysis alone misleading.
  • Lung mass (m) is calculated as dm multiplied by VLx.

Purpose of the Study:

  • To investigate lung mass in emphysema patients using CT scans.
  • To compare lung mass between emphysema patients and healthy individuals.
  • To correlate lung mass with pulmonary function tests.

Main Methods:

  • CT scans of the whole lung were performed on 24 emphysema patients and 16 healthy subjects at functional residual capacity (FRC).
  • Pulmonary function tests including airway resistance, FEV1, FVC, TLC, CO transfer capacity, compliance, and blood gases were conducted.

Related Experiment Videos

  • Mean lung density (dm), lung volume (VLx), and lung mass (m) were calculated from CT data.

    • Main Results:

    • Emphysema patients had lower dm but greater m (1,303 g) compared to healthy subjects (997 g).
    • dm correlated with FEV1, FEV1/FVC, and TLC, but m did not correlate with any functional indices.
    • Most emphysema patients (22/24) exhibited normal or increased lung mass.

    Conclusions:

    • Emphysema is associated with normal or increased lung mass, challenging previous assumptions.
    • Oversecretion or chronic inflammation leading to new tissue synthesis are potential explanations for increased lung mass.
    • Lung mass calculation offers a novel metric for emphysema assessment, independent of traditional functional indices.