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Parathyroid carcinoma.

N Rawat1, N Khetan, D W Williams

  • 1Department of General Surgery, Morriston Hospital, Swansea, UK.

The British Journal of Surgery
|October 21, 2005
PubMed
Summary
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Parathyroid carcinoma is a rare cancer. Surgical removal is standard, and adjuvant radiotherapy may improve survival for this rare endocrine malignancy.

Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Parathyroid carcinoma is a rare malignancy, accounting for 0.5-5% of primary hyperparathyroidism cases.
  • This review covers the pathogenesis, pathology, clinical features, diagnosis, and management of parathyroid carcinoma.

Purpose of the Study:

  • To review the current literature on parathyroid carcinoma.
  • To discuss the latest findings in the pathogenesis, diagnosis, and management of this rare cancer.

Main Methods:

  • A comprehensive Medline search was conducted for English language articles published between 1970 and 2005.
  • Keywords included 'parathyroid carcinoma', 'pathology', 'genetics', 'management', and 'radiotherapy'.
  • Secondary references were identified from key retrieved articles.

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Main Results:

  • The exact etiology of parathyroid carcinoma is still unknown.
  • The HRPT2 gene has recently been implicated in the pathogenesis of parathyroid carcinoma.
  • Surgical resection is the established gold standard treatment.
  • Adjuvant radiotherapy shows a survival benefit and is increasingly recommended.

Conclusions:

  • The precise cause of parathyroid carcinoma remains elusive.
  • The HRPT2 gene presents a potential genetic target for future research and therapy.
  • Surgical management is crucial, and adjuvant radiotherapy offers a survival advantage.