[Haemostatic and fibrinolytic variables in women with anorexia nervosa]

The aim of this study was to evaluate haemostatic variables in women with anorexia nervosa --AN.

23 obese female patients, and 39 female anorexic patients diagnosed acc. to DSM-IV and ICD-10 criteria were recruited. The studied group was compared to a control group--37 healthy female volunteers. BMI was calculated for AN, obese, and the control group. The following measurements were taken: prothrombin index, prothrombin time, thrombin time, fibrinogen, factor VII, ATIII, D-dimers, INR, APTT, protein C and PAI-1 activity, t-PA activity, PAI-1 antigen, t-PA antigen, glucose level, insulin level, E2 and total fat.

In the AN group the INR, prothrombin time, PAI-1 activity, t-PA activity, protein C level were increased, whereas PAI-1 antigen, t-PA antigen, prothrombin index, fasting insulin level and fasting glucose level were decreased.

We conclude that, in the AN group, an impaired fibrinolysis and coagulation are observed and there is a correlation between fibrinolytic and coagulation parameters and carbohydrate metabolism.