Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A variable-energy electron microbeam: a unique modality for targeted low-LET radiation.

Marianne B Sowa1, Mark K Murphy, John H Miller

  • 1Pacific Northwest National Laboratory, Richland, Washington 99352, USA. Marianne.sowa@pnl.gov

Radiation Research
|October 22, 2005
PubMed
Summary

Researchers developed a low-cost electron microbeam to simulate radiation damage from X-rays and gamma rays. This tool allows precise cell targeting and comparison with conventional radiation sources.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Web-based cardiovascular disease risk prediction using machine learning.

Frontiers in artificial intelligence·2026
Same author

Bacteriocin prediction through cross-validation-based and hypergraph-based feature evaluation approaches.

Frontiers in bioinformatics·2025
Same author

Mechanisms Governing Noble Gas Adsorption in a Copper-Based Metal-Organic Framework.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Agent-based modeling for psychological research on social phenomena.

The American psychologist·2025
Same author

Preparation and stability characterization of flavour ingredients in E-liquids for preclinical assessment of electronic nicotine delivering system products: a case study of 38 flavour ingredients in a single mixture.

Journal of analytical toxicology·2025
Same author

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies.

Medicinal research reviews·2024

Area of Science:

  • Radiation Biology
  • Medical Physics
  • Biophysics

Background:

  • Conventional X-ray and gamma-ray sources are widely used for radiation research.
  • Simulating specific radiation damage patterns in cells is crucial for understanding biological effects.
  • Existing microbeam technologies may have limitations in cost or energy variability.

Purpose of the Study:

  • To design and construct a low-cost, variable-energy electron microbeam.
  • To mimic radiation damage patterns produced by gamma and X rays.
  • To enable direct comparison between microbeam and conventional radiation sources.

Main Methods:

  • Utilized energetic electrons to create a variable-energy electron microbeam.
  • Engineered the microbeam with two operating modes: single-cell targeting and pseudo broad-beam.

Related Experiment Videos

  • Adjusted incident electron energy to control exposure along electron tracks.

    • Main Results:

    • Successfully designed and constructed a low-cost, variable-energy electron microbeam.
    • The microbeam can access lower linear energy transfer (LET) regions, similar to gamma and X-ray sources.
    • Demonstrated selective exposure of cells to different parts of energetic electron tracks, including track ends.

    Conclusions:

    • The developed electron microbeam offers a versatile and cost-effective tool for radiation research.
    • It provides a means to simulate and study radiation damage mimicking conventional sources.
    • The variable energy capability allows for detailed investigation of cellular responses to different radiation track structures.