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Updated: Aug 15, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Variability in pain expression characteristics in former preterm infants
Karel Allegaert1, Hugo Devlieger, Dominiek Bulckaert
1Department of Pediatrics, University Hospital Gasthuisberg Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
Insights
Pain expression in preterm infants is linked to their postconceptional age (PCA) and length of stay (LOS). These factors influence how infants react to pain, highlighting the need for careful pain management.
Area of Science:
- Neonatal care
- Pediatric pain research
- Infant development
Background:
- Preterm infants exhibit unique pain responses.
- Systematic pain evaluation and treatment are crucial for this population.
- Understanding pain expression aids in optimizing care for vulnerable infants.
Purpose of the Study:
- To characterize pain expression in former preterm infants during their first year.
- To investigate the influence of clinical factors on pain indicators.
- To provide data for improved pain management strategies in this cohort.
Main Methods:
- Utilized Modified Behavioral Pain Scale (MBPS) and Visual Analogue Scale (VAS).
- Collected data on crying time and heart rate during immunizations.
- Analyzed the impact of postconceptional age (PCA), surgery, ventilation, fentanyl, and length of stay (LOS) on pain parameters.
Main Results:
- 121 procedures in 49 infants were analyzed.
- Significant correlations found between PCA and heart rate responses.
- Length of stay (LOS) correlated with crying time, suggesting cumulative pain effects.
Conclusions:
- Postconceptional age (PCA) influences heart rate changes, reflecting maturation.
- Length of stay (LOS) impacts pain expression, possibly due to cumulative procedural pain.
- Findings underscore the importance of considering developmental and cumulative factors in infant pain assessment.
Objectives:
To document pain expression characteristics in former preterm infants in the first year of life in whom systematic evaluation and treatment of pain was provided.
Methods:
Data on the Modified Behavioral Pain Scale (MBPS), Visual Analogue Scale (VAS, crying time and heart rate were collected during immunization. The effect of clinical characteristics {postconception and gestational age [PCA], surgery, ventilation, fentanyl, length of stay (LOS)} on bio-behavioral parameters was evaluated.
Results:
121 procedures were recorded in 49 infants. GA was 28 (25-32) weeks. PCA was 60 (34-90) weeks. Median MBPS was 8 (2-10), median crying time 44 (0-112) s. Median pre-procedural heart rate was 144 (103-201) and increased to 184 (147-220) afterwards, resulting in a relative increase of 29 (5-99)%. Median VAS score was 7 (1-10). Significant correlations of PCA with pre-procedural heart rate (r=-0.36) and with relative increase in heart rate (r=0.33) were identified. A correlation of LOS on crying time (r=0.37) was observed.
Conclusions:
Correlations of PCA with pre-procedural and relative increase in heart rate reflect the maturational decrease in heart rate. LOS had an effect on pain expression, potentially reflecting the impact of cumulative 'minor' procedural pain.
Related Concept Videos
Analgesia and Pain Management
Pain
