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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Arrhythmias associated with respiratory syncytial virus infection
Stephen D Playfor1, Abdul Khader
1Paediatric Intensive Care Unit, Royal Manchester Children's Hospital, Pendlebury, Manchester, UK. stephen.playfor@cmmc.nhs.uk
Insights
A severe respiratory syncytial virus infection in an infant caused dangerous heart arrhythmias due to low magnesium. Prompt magnesium sulfate treatment resolved the arrhythmias, revealing an underlying atrial septal defect.
Area of Science:
- Pediatrics
- Cardiology
- Infectious Diseases
Background:
- Respiratory syncytial virus (RSV) is a common cause of respiratory illness in infants.
- Cardiac arrhythmias can be serious complications in pediatric patients.
- Electrolyte imbalances, such as hypomagnesemia, can precipitate cardiac events.
Observation:
- A 7-week-old infant presented with RSV infection.
- The infant abruptly developed complex cardiac arrhythmias.
- A concurrent finding was a low serum magnesium level.
Findings:
- Intravenous magnesium sulfate administration successfully treated the infant's cardiac arrhythmias.
- The infant was later diagnosed with a significant atrial septal defect (ASD).
- This case highlights the potential link between RSV, hypomagnesemia, and cardiac arrhythmias in infants.
Implications:
- Early recognition and management of hypomagnesemia are crucial in infants with severe infections.
- Magnesium supplementation should be considered in pediatric patients with unexplained arrhythmias.
- Screening for congenital heart defects may be warranted in infants presenting with severe arrhythmias and electrolyte disturbances.
Abstract:
Summary A 7-week-old infant with respiratory syncytial virus infection abruptly developed complex cardiac arrhythmias in association with a low serum magnesium level. The arrhythmias were successfully treated with a single intravenous infusion of magnesium sulfate. The child was subsequently found to have a significant atrial septal defect.
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