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Booster immunization of antigen primed mice with anti-idiotypic T cells generates antigen-specific memory T cell

Girdhari Lal1, M S Shaila, Rabindranath Nayak

  • 1Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.

Vaccine
|October 22, 2005
PubMed

Immunological memory is characterized by quick and enhanced immune response after re-exposure to the same antigen. In the present work, we have shown that anti-idiotypic T cells are generated in mice after immunization with idiotypic T cell clone or polyclonal T cell specific for nucleocapsid protein of Rinderpest virus. Further, we have shown that N specific idiotypic T cell receptors from apoptotic idiotypic T cells are processed by bone marrow derived dendritic cells and presented to cognate anti-idiotypic T cells. Evidence has been provided for the existence of antigen specific T cell idiotypic network in the body. Boosting with antigen specific anti-idiotypic T cells generates memory response in the antigen-primed mice.

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