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Updated: Aug 15, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
The Notch pathway in cancer: differentiation gone awry
Jonas Sjölund1, Christina Manetopoulos, Marie-Thérése Stockhausen
1Department of Laboratory Medicine, Division of Molecular Medicine, University Hospital MAS, Entrance 78, 3rd Floor, SE-205 02 Malmö, Sweden.
Abstract:
The Notch signalling cascade influences several key aspects of normal development by regulating differentiation, proliferation and apoptosis. Its association to human cancer is firmly established in T-cell leukaemia where point mutations or chromosomal translocations lead to constitutive signalling. Accumulating data indicate that deregulated Notch activity is involved also in the genesis of other human cancers, such as pancreatic cancer, medulloblastoma and mucoepidermoid carcinoma. In these tumours, the oncogenic effect of Notch signalling reflects an aberrant recapitulation of the highly tissue-specific function of the cascade during normal development and in tissue homeostasis.
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