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Related Concept Videos

Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Endocytosis01:16

Endocytosis

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Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Related Experiment Video

Updated: Jan 8, 2026

Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells
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Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells

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Eater: a big bite into phagocytosis.

Deniz Ertürk-Hasdemir1, Neal Silverman

  • 1Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA.

Cell
|October 22, 2005
PubMed
Summary
This summary is machine-generated.

Specialized blood cells engulf microbes, a key part of innate immunity. In Drosophila, the Eater scavenger receptor is vital for recognizing and phagocytosing bacteria.

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Area of Science:

  • Immunology
  • Cell Biology
  • Entomology

Background:

  • Phagocytosis is a fundamental immune mechanism for clearing pathogens.
  • Innate immunity relies on cellular processes to defend against microbial invasion.
  • Specialized blood cells, like phagocytes, are critical for pathogen recognition and elimination.

Purpose of the Study:

  • To investigate the role of scavenger receptors in Drosophila innate immunity.
  • To identify specific molecules involved in bacterial recognition and phagocytosis in fruit flies.
  • To elucidate the function of the Eater receptor in the context of host-pathogen interactions.

Main Methods:

  • Utilized Drosophila melanogaster as a model organism.
  • Employed genetic and cellular assays to study phagocytosis.
  • Investigated the function of the Eater scavenger receptor in immune responses.

Main Results:

  • Demonstrated that Eater is a scavenger receptor crucial for immune recognition.
  • Showed Eater mediates the phagocytosis of bacteria in Drosophila.
  • Highlighted the importance of Eater in the fruit fly's defense against microbial pathogens.

Conclusions:

  • The Eater scavenger receptor plays a significant role in Drosophila's innate immune system.
  • Eater facilitates the recognition and engulfment of bacteria by specialized blood cells.
  • This finding provides insights into conserved mechanisms of phagocytosis across species.